Name: L-5-Methyltetrahydrofolate Calcium Powder，vL-5-MTHF-Ca，5-MTHF，folate supplement，CAS 151533-22-1
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DETAILS
FUNCTION
Application
COA

DETAILS

What is L-5-Methyltetrahydrofolate Calcium Powder

L-5-Methyltetrahydrofolate Calcium Powder (L-5-MTHF-Ca) represents an active variant of folate (Vitamin B9), differentiated from conventional folic acid by its unique biochemical attributes. Presented as white to light yellow crystalline powder, it boasts an HPLC assay range of 95.0%–102.0% and a melting point exceeding 300°C. Registered under CAS No. 151533-22-1 with molecular formula C₂₀H₂₇CaN₇O₆, it serves as a key substrate for prenatal nutrition, medical nutrition and broad-spectrum dietary supplement development.

FUNCTION

Active Folate, Direct Utilization

L-5-MTHF-Ca is an active folate variant featuring distinctive biochemical traits compared with folic acid. It acts as a reliable core substrate for developing prenatal nutrition and general dietary supplement matrices.

Supports Homocysteine Metabolism

L-5-Methyltetrahydrofolate Calcium Powder engages in endogenous biochemical methylation pathways associated with homocysteine turnover. This active folate substrate is extensively utilized in the development and manufacturing of diverse dietary nutritional matrices.

Fetal Neural Development & Maternal Health

L-5-Methyltetrahydrofolate Calcium is a premium active folate raw material that participates in human endogenous biochemical synthesis and metabolism processes. It is widely incorporated into professional prenatal and maternal nutritional supplement formulations to optimize the nutritional value of finished products.

Red Blood Cell Formation

L-5-MTHF-Ca participates in fundamental endogenous biochemical processes including DNA synthesis and cell metabolism. As a high-activity folate raw material, it is widely applied in a variety of nutritional supplement formulations for daily health scenarios.

Application

Prenatal & Postnatal Supplements

Featuring excellent bioavailability, L-5-MTHF-Ca is a high-quality folate substrate widely integrated into prenatal multivitamin matrices and professional maternal nutritional formulations. It also supports the development of postnatal nutritional products, delivering versatile application value in maternal nutrition fields.

Cardiovascular Health Products

L-5-MTHF-Ca is widely formulated into cardiovascular nutritional matrices and integrated dietary supplement systems. It enables scientific compounding with vitamin B6, vitamin B12 and betaine, offering flexible and professional substrate solutions for customized nutritional product innovation.

General Nutritional Supplements

L-5-MTHF-Ca can be incorporated into multivitamins, mineral blends, B-complex formulations and single-component active folate products. It is a commonly used raw material for daily wellness nutritional supplements and meets the formulation demands of diversified nutritional product lines.

Medical & Clinical Nutrition

L-5-MTHF-Ca functions as a high-specification nutritional substrate extensively utilized in medical food and clinical nutrition systems. It supports the customized development of professional-grade nutritional formulations for clinical application scenarios.

COA

ITEMS	SPECIFICATION	RESULT	METHOD
Calcium L-5-methyltetrahydrofolate (Anhydrous and solvent free)	95.0~102.0%	97.62%	HPLC \|\| USP
L-5-Methyltetrahydrofolate (L-5-MTHF)	72.0~87.0%	82.27%	Calculation
Calcium (Anhydrous and solvent free)	7.0~8.5%	7.78%	Titrimetry\|\| USP
Total Related Compounds	NMT 2.5%	0.36%	HPLC \|\| USP
4-Aminobenzoylglutamiv Acid	NMT 0.5%	Not Detected	HPLC \|\| USP
4a-Hydroxy-5-Methyltetrahydrofolic Acid	NMT 0.5%	0.15%	HPLC \|\| USP
(6R and 6S)-Mefox	NMT 1.0%(sum of 6R and 6S)	Not Detected	HPLC \|\| USP
Tetrahydrofolic Acid	NMT 0.5%	Not Detected	HPLC \|\| USP
7,8-Dihydrofolic Acid	NMT 0.5%	Not Detected	HPLC \|\| USP
Folic Acid	NMT 0.5%	Not Detected	HPLC \|\| USP
5,10-Methylenetetrahydrofolic Acid	NMT 0.5%	Not Detected	HPLC \|\| USP
5-Methylenetetrahydropteroic Acid	NMT 0.5%	0.09%	HPLC \|\| USP
Dimethyltetrahydrofolic Acid	NMT 0.15%	Not Detected	HPLC \|\| USP
Enantiomeric Purity (D-5-Methyltetrahydrofolate)	NMT 1.0%	0.5%	HPLC \|\| USP
Identification	The retention time of the principle peak should conform with standard	Conform	HPLC \|\| USP

PHYSICAL CHARACTERISTICS

Water Determination (K-F)	6.0~17.0%	8.43%	USP Method Ic
Particle Size	NLT 90% Through 80 mesh	Conform	Analytical sieving \|\| USP
Bulk Density	NLT 0.2g/ml	0.21g/ml	USP Method I

CHEMICAL CHARACTERISTICS

Residual Solvent	Ethanol: NMT 5,000ppm	Not Detected	GC \|\| USP
	2-Propanol: NMT 5,000ppm	Not Detected	GC \|\| USP
Platinium	NMT 10ppm	＜0.01ppm	ICP-MS \|\| USP
Boron	NMT 50ppm	13.2ppm	ICP-MS \|\| USP
Chloride	NMT 0.5%	0.15%	Titrimetry\|\| USP
Heavy Metals(as Pb)	NMT 20ppm	Conform	USP Method II
Arsenic (As)	NMT 1.5ppm	0.01ppm	ICP-MS \|\| USP
Lead (Pb)	NMT 1.0ppm	Not Detected	ICP-MS \|\| USP
Cadmium (Cd)	NMT 0.5ppm	Not Detected	ICP-MS \|\| USP
Mercury (Hg)	NMT 1.5ppm	Not Detected	ICP-MS \|\| USP

MICROBIOLOGICAL CHARACTERISTICS

Total Plate Count	NMT 5,000cfu/g	＜10cfu/g	USP
Total Yeast & Mold	NMT 500cfu/g	＜10cfu/g	USP
E. Coli	Not Detected in(g) 10	Not Detected	USP
Salmonella	Not Detected in(g) 25	Not Detected	USP
Staphylococcus aureus	Not Detected in(g) 10	Not Detected	USP
Pseudomonas aeruginosa	Not Detected in(g) 10	Not Detected	USP
Candida albicans	Not Detected in(g) 10	Not Detected	USP
Clostridia	Not Detected in(g) 10	Not Detected	USP