L-5-Methyltetrahydrofolate Calcium Powder
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What is L-5-Methyltetrahydrofolate Calcium Powder
Active Folate, Direct Utilization
L-5-MTHF-Ca is an active folate variant featuring distinctive biochemical traits compared with folic acid. It acts as a reliable core substrate for developing prenatal nutrition and general dietary supplement matrices.
Supports Homocysteine Metabolism
L-5-Methyltetrahydrofolate Calcium Powder engages in endogenous biochemical methylation pathways associated with homocysteine turnover. This active folate substrate is extensively utilized in the development and manufacturing of diverse dietary nutritional matrices.
Fetal Neural Development & Maternal Health
L-5-Methyltetrahydrofolate Calcium is a premium active folate raw material that participates in human endogenous biochemical synthesis and metabolism processes. It is widely incorporated into professional prenatal and maternal nutritional supplement formulations to optimize the nutritional value of finished products.
Red Blood Cell Formation
L-5-MTHF-Ca participates in fundamental endogenous biochemical processes including DNA synthesis and cell metabolism. As a high-activity folate raw material, it is widely applied in a variety of nutritional supplement formulations for daily health scenarios.
Prenatal & Postnatal Supplements
Featuring excellent bioavailability, L-5-MTHF-Ca is a high-quality folate substrate widely integrated into prenatal multivitamin matrices and professional maternal nutritional formulations. It also supports the development of postnatal nutritional products, delivering versatile application value in maternal nutrition fields.
Cardiovascular Health Products
L-5-MTHF-Ca is widely formulated into cardiovascular nutritional matrices and integrated dietary supplement systems. It enables scientific compounding with vitamin B6, vitamin B12 and betaine, offering flexible and professional substrate solutions for customized nutritional product innovation.
General Nutritional Supplements
L-5-MTHF-Ca can be incorporated into multivitamins, mineral blends, B-complex formulations and single-component active folate products. It is a commonly used raw material for daily wellness nutritional supplements and meets the formulation demands of diversified nutritional product lines.
Medical & Clinical Nutrition
L-5-MTHF-Ca functions as a high-specification nutritional substrate extensively utilized in medical food and clinical nutrition systems. It supports the customized development of professional-grade nutritional formulations for clinical application scenarios.
| ITEMS | SPECIFICATION | RESULT | METHOD |
| Calcium L-5-methyltetrahydrofolate (Anhydrous and solvent free) | 95.0~102.0% | 97.62% | HPLC || USP |
| L-5-Methyltetrahydrofolate (L-5-MTHF) | 72.0~87.0% | 82.27% | Calculation |
| Calcium (Anhydrous and solvent free) | 7.0~8.5% | 7.78% | Titrimetry|| USP |
| Total Related Compounds | NMT 2.5% | 0.36% | HPLC || USP |
| 4-Aminobenzoylglutamiv Acid | NMT 0.5% | Not Detected | HPLC || USP |
| 4a-Hydroxy-5-Methyltetrahydrofolic Acid | NMT 0.5% | 0.15% | HPLC || USP |
| (6R and 6S)-Mefox | NMT 1.0%(sum of 6R and 6S) | Not Detected | HPLC || USP |
| Tetrahydrofolic Acid | NMT 0.5% | Not Detected | HPLC || USP |
| 7,8-Dihydrofolic Acid | NMT 0.5% | Not Detected | HPLC || USP |
| Folic Acid | NMT 0.5% | Not Detected | HPLC || USP |
| 5,10-Methylenetetrahydrofolic Acid | NMT 0.5% | Not Detected | HPLC || USP |
| 5-Methylenetetrahydropteroic Acid | NMT 0.5% | 0.09% | HPLC || USP |
| Dimethyltetrahydrofolic Acid | NMT 0.15% | Not Detected | HPLC || USP |
| Enantiomeric Purity (D-5-Methyltetrahydrofolate) | NMT 1.0% | 0.5% | HPLC || USP |
| Identification | The retention time of the principle peak should conform with standard | Conform | HPLC || USP |
PHYSICAL CHARACTERISTICS
| Water Determination (K-F) | 6.0~17.0% | 8.43% | USP Method Ic |
| Particle Size | NLT 90% Through 80 mesh | Conform | Analytical sieving || USP |
| Bulk Density | NLT 0.2g/ml | 0.21g/ml | USP Method I |
CHEMICAL CHARACTERISTICS
| Residual Solvent | Ethanol: NMT 5,000ppm | Not Detected | GC || USP |
| 2-Propanol: NMT 5,000ppm | Not Detected | GC || USP | |
| Platinium | NMT 10ppm | ＜0.01ppm | ICP-MS || USP |
| Boron | NMT 50ppm | 13.2ppm | ICP-MS || USP |
| Chloride | NMT 0.5% | 0.15% | Titrimetry|| USP |
| Heavy Metals(as Pb) | NMT 20ppm | Conform | USP Method II |
| Arsenic (As) | NMT 1.5ppm | 0.01ppm | ICP-MS || USP |
| Lead (Pb) | NMT 1.0ppm | Not Detected | ICP-MS || USP |
| Cadmium (Cd) | NMT 0.5ppm | Not Detected | ICP-MS || USP |
| Mercury (Hg) | NMT 1.5ppm | Not Detected | ICP-MS || USP |
MICROBIOLOGICAL CHARACTERISTICS
| Total Plate Count | NMT 5,000cfu/g | ＜10cfu/g | USP |
| Total Yeast & Mold | NMT 500cfu/g | ＜10cfu/g | USP |
| E. Coli | Not Detected in(g) 10 | Not Detected | USP |
| Salmonella | Not Detected in(g) 25 | Not Detected | USP |
| Staphylococcus aureus | Not Detected in(g) 10 | Not Detected | USP |
| Pseudomonas aeruginosa | Not Detected in(g) 10 | Not Detected | USP |
| Candida albicans | Not Detected in(g) 10 | Not Detected | USP |
| Clostridia | Not Detected in(g) 10 | Not Detected | USP |
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