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Piperine is the alkaloid responsible for the pungency of black and long pepper, as well as chavicine (an isomer of piperine). Piperine is often added to prepared foods to enhance aroma and to promote drug absorption and increase the effectiveness of drug functions. Clinically, it induces sedation (sedative effect) or induces sleep (hypnotic effect), and is used to make anticonvulsants, antidepressants, and muscle relaxants.
Piperine has also been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and animal studies, and other enzymes important in drug metabolism. By inhibiting drug metabolism, piperine can increase the bioavailability of various compounds.
1. Piperine is an alkaloid in black pepper, mainly used to treat digestive problems and promote nutrient absorption
2. It can improve the bioavailability of other ingredients, making it an important ally in the fight against heart disease.
3. It also protects red blood cells from damage
1. Black pepper also lowers high cholesterol, including total and LDL cholesterol
2. It improves blood circulation and prevents blood clots
3. Piperine may also stimulate other intestinal enzymes such as amylase, lipase, and trypsin.